Imaging the brain anatomy and electrophysiologic activity is critical to many applications including electromagnetic dosimetry, neurostimulation, brain computer interfaces, and the diagnosis of diseases such as cancer, epilepsy, and Parkinson’s. Two types of imaging exist: structural and functional; the former targets the brain structures and material properties while the latter focuses on the brain (electrochemical) activity. Until now, structural imaging has been underlying most functional modalities that are improved by better structural knowledge. CYCLE proposes to close the loop and, for the first time, to reverse the process by improving structural imaging with functional imaging. Iterating this cycled scheme would be game-changing, since plethora of functional and anatomical imaging techniques and their applications would be improved at low and high frequencies.