Intercellular coupling and synchronization between peripheral circadian clocks

The circadian clock in mammalians is governed by an oscillatory gene network present in virtually every cell of the body. The goal of InSync is to study and understand the intercellular mechanisms that lead to robust rhythms and clock synchronization among the cellular clocks of peripheral organs such as the liver. To achieve this goal, InSync combines mathematical modeling and biological experiments.

InSync in an ANR funded project, started in December 2022, it has three partners:

• Inria, team Biocore
• CNRS, iBV (Institut de Biologie de Valrose)
• INRAE, Jouy-en-Josas