Lars Malmström Division of Infection Medicine, Department of Clinical Sciences Lund, Faculty of Medicine, Lund University, Lund, Sweden Antimicrobial resistance (AMR) is a global public health and development threat. Vaccines are the most effective single measure to protect populations against infectious diseases. They are also predicted to play a critical…
Sergei Grudinin LJK CNRS, Grenoble, France Simplification of dynamic systems has numerous biological applications, from protein domain detection [1] to automatic coarse-graining in molecular simulations [2, 3]. Various solutions have been proposed for this problem, such as using graph theory [4-5], examining the covariance patterns in elastic network models [6],…
Nicols Soler Université de Lorraine, Dynamic, Nancy Bacterial genomes mainly evolve through horizontal gene exchanges. They nobably enable the spreading of virulence or antibiotic resistance genes. A major mechanism for these genetic exchanges is bacterial conjugation, which requires cell-cell contact. It is mediated by mobile genetic elements such as conjugative…
Elodie Laine Laboratoire de Biologie Computationnelle et Quantitative, Sorbonne Université-CNRS, Paris, France Proteins play a central role in biological processes, and understanding their conformational variability is crucial for unraveling their functional mechanisms. Recent advancements in high-throughput technologies have enhanced our knowledge of protein structures, yet predicting their multiple conformational states…
Alessandra Carbone Laboratoire de Biologie Computationnelle et Quantitative, Sorbonne Université-CNRS, Paris, France Accurately annotating missense variants is pivotal in the fight against rare diseases. Despite advancements, such as the breakthrough AlphaMissense model featured in Science on September 23, 2023, clinicians continue to face the challenge of distinguishing pathogenic rare variants…
Chris Chipot Unité Mixte de Recherche, CNRS/UL 7565, Université de Lorraine, Vandoeuvre-les-Nancy, France At the atomic scale, simulating transitions between stable states of the free-energy landscape, often impeded by sluggish molecular processes, constitutes a daunting challenge. One common approach to overcoming these barriers and speeding up dynamics is supplied by…
Massimiliano Bonomi Institut Pasteur, Université Paris Cité, CNRS UMR 3528, Computational Structural Biology Unit, Paris, France Understanding the molecular mechanisms employed by biological systems to carry out their functions is often essential for rationally targeting associated diseases. In many cases, determining the three- dimensional (3D) structure of these systems provides…
