Martin Pacesa LPDI, EPFL, Switzerland Protein–protein interactions (PPIs) are at the core of all key biological processes. However, the complexity of the structural features that determine PPIs makes their design challenging. We present BindCraft, an open-source and automated pipeline for de novo protein binder design with experimental success rates of…
BIGNON Emmanuelle;A QIU Yuya;A SMIRNOVA Ekaterina;B SCHULTZ Patrick;B PAPAI Gabor;B BEN SHEM AdamB A) Université de Lorraine and CNRS, UMR 7019 LPCT, Nancy, France; B) Department of Integrated Structural Biology, IGBMC, CNRS and INSERM, UMR 7104-UMR-S 1258, Illkirch, France emmanuelle.bignon@univ-lorraine.fr Gene activity is tightly controlled by reversible chemical modifications called…
Matthieu Chavent Laboratoire de Microbiologie et Génétique Moléculaires (LMGM), Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS, Toulouse 31400, France Mycobacterium tuberculosis, the pathogen responsible for the infectious disease tuberculosis, is known for its thick and waxy envelope constituted of numerous complex lipids (1). These lipids act both…
Patrick Schultz IGBMC, UMR 7104 CNRS, U1258 INSERM, Université de Strasbourg Changqing Li, Ekaterina Smirnova, Charlotte Schnitzler, Corinne Crucifix, Arnaud Poterszman, Patrick Schultz, Gabor Papaiand Adam Ben-Shem, in collaboration with Jean Paul Concordet (Museum National d’Histoire Naturelle, U 1154 Inserm, UMR 7196 CNRS) Chromatin structure is a key regulator of…
Paulo C. T. Souza Laboratoire de Biologie et Modélisation de la Cellule, CNRS, UMR 5239, Inserm, U1293, Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, Centre Blaise Pascal de Simulation et de Modélisation Numérique, 46 Allée d’Italie, 69364, Lyon, France. The Martini model is among the most popular…
Lars Malmström Division of Infection Medicine, Department of Clinical Sciences Lund, Faculty of Medicine, Lund University, Lund, Sweden Antimicrobial resistance (AMR) is a global public health and development threat. Vaccines are the most effective single measure to protect populations against infectious diseases. They are also predicted to play a critical…
Sergei Grudinin LJK CNRS, Grenoble, France Simplification of dynamic systems has numerous biological applications, from protein domain detection [1] to automatic coarse-graining in molecular simulations [2, 3]. Various solutions have been proposed for this problem, such as using graph theory [4-5], examining the covariance patterns in elastic network models [6],…
Nicols Soler Université de Lorraine, Dynamic, Nancy Bacterial genomes mainly evolve through horizontal gene exchanges. They nobably enable the spreading of virulence or antibiotic resistance genes. A major mechanism for these genetic exchanges is bacterial conjugation, which requires cell-cell contact. It is mediated by mobile genetic elements such as conjugative…
Elodie Laine Laboratoire de Biologie Computationnelle et Quantitative, Sorbonne Université-CNRS, Paris, France Proteins play a central role in biological processes, and understanding their conformational variability is crucial for unraveling their functional mechanisms. Recent advancements in high-throughput technologies have enhanced our knowledge of protein structures, yet predicting their multiple conformational states…
Alessandra Carbone Laboratoire de Biologie Computationnelle et Quantitative, Sorbonne Université-CNRS, Paris, France Accurately annotating missense variants is pivotal in the fight against rare diseases. Despite advancements, such as the breakthrough AlphaMissense model featured in Science on September 23, 2023, clinicians continue to face the challenge of distinguishing pathogenic rare variants…
