Martin Pacesa LPDI, EPFL, Switzerland Protein–protein interactions (PPIs) are at the core of all key biological processes. However, the complexity of the structural features that determine PPIs makes their design challenging. We present BindCraft, an open-source and automated pipeline for de novo protein binder design with experimental success rates of…
BIGNON Emmanuelle;A QIU Yuya;A SMIRNOVA Ekaterina;B SCHULTZ Patrick;B PAPAI Gabor;B BEN SHEM AdamB A) Université de Lorraine and CNRS, UMR 7019 LPCT, Nancy, France; B) Department of Integrated Structural Biology, IGBMC, CNRS and INSERM, UMR 7104-UMR-S 1258, Illkirch, France emmanuelle.bignon@univ-lorraine.fr Gene activity is tightly controlled by reversible chemical modifications called…
Matthieu Chavent Laboratoire de Microbiologie et Génétique Moléculaires (LMGM), Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS, Toulouse 31400, France Mycobacterium tuberculosis, the pathogen responsible for the infectious disease tuberculosis, is known for its thick and waxy envelope constituted of numerous complex lipids (1). These lipids act both…
Patrick Schultz IGBMC, UMR 7104 CNRS, U1258 INSERM, Université de Strasbourg Changqing Li, Ekaterina Smirnova, Charlotte Schnitzler, Corinne Crucifix, Arnaud Poterszman, Patrick Schultz, Gabor Papaiand Adam Ben-Shem, in collaboration with Jean Paul Concordet (Museum National d’Histoire Naturelle, U 1154 Inserm, UMR 7196 CNRS) Chromatin structure is a key regulator of…
Paulo C. T. Souza Laboratoire de Biologie et Modélisation de la Cellule, CNRS, UMR 5239, Inserm, U1293, Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, Centre Blaise Pascal de Simulation et de Modélisation Numérique, 46 Allée d’Italie, 69364, Lyon, France. The Martini model is among the most popular…
Here is the program of NCSB 2024 (click on each title to read the abstract): 9:30 – 9:45: Welcome and introduction9:45 – 10:30: Massimiliano Bonomi (Institut Pasteur, CNRS, Paris) – Protein structural ensembles from 3D and 2D cryo-EM data10:30 – 11:00: Coffee break11:00 – 11:30: Chris Chipot (Université de Lorraine,…
We are happy to announce that the second NCSB will be held on July 9th at Nancy , with the help of the LORIA and Inria. We have the pleasure of hosting internationally distinguished experts. Here is the program. Please remember to register! Registration is free but mandatory! The seminar will…
Lars Malmström Division of Infection Medicine, Department of Clinical Sciences Lund, Faculty of Medicine, Lund University, Lund, Sweden Antimicrobial resistance (AMR) is a global public health and development threat. Vaccines are the most effective single measure to protect populations against infectious diseases. They are also predicted to play a critical…
Sergei Grudinin LJK CNRS, Grenoble, France Simplification of dynamic systems has numerous biological applications, from protein domain detection [1] to automatic coarse-graining in molecular simulations [2, 3]. Various solutions have been proposed for this problem, such as using graph theory [4-5], examining the covariance patterns in elastic network models [6],…
Nicols Soler Université de Lorraine, Dynamic, Nancy Bacterial genomes mainly evolve through horizontal gene exchanges. They nobably enable the spreading of virulence or antibiotic resistance genes. A major mechanism for these genetic exchanges is bacterial conjugation, which requires cell-cell contact. It is mediated by mobile genetic elements such as conjugative…
