Title: Bistability of lamellipodial fragments
Abstract: In experiments bistability of lamellipodial fragments has been observed with perturbation induced switching between a nonpolarized-nonmoving and a polarized-moving state. The Filament Based Lamellipodium Model, a two-dimensional, anisotropic, two-phase model of the lamellipodium is used to explain the bistability as a phenomenon induced by actin-myosin interaction. The bistability is obtained both analytically in a strongly simplified model, and numerically in simulations of the full model.