Séances du jeudi matin de 10h à 12h (alternées entre ICJ, UMPA, Institut Fourier)
Lundi 8 avril: Journée 2 à Marseille
16 mai 2024 : ICJ, Lyon
Audrey Denizot (AIstroSight, Inria Lyon) : Towards elucidating astrocyte function in the brain: insights from stochastic spatially-extended models
Résumé: Astrocytes are cells of the brain that have recently emerged as key regulators of signal transmission, taking part in higher brain functions such as memory and learning. Astrocytes communicate with neighboring cells with changes in intracellular calcium concentration: Ca2+ signals. Most of these signals occur at the nanoscale, hindering their study in live tissue, so that computational approaches are essential to gain insights into their dynamics. To take into account the complex morphology of astrocytes and the stochasticity of reactions occuring in the resulting nanoscopic compartments, we have developed reaction-diffusion particle-based and voxel-based models of astrocyte Ca2+ dynamics. Our simulations revealed mechanisms by which spatial factors such as the clustering of Ca2+ channels, Ca2+ buffering, ER shape and distribution influence the spatio-temporal properties of Ca2+ signals. Astrocytes and their Ca2+ signals are essential to the functioning of the nervous system and are altered in most brain disorders. As research has for long focused on treating neurons, little is known about astrocyte (patho-)physiology and better characterizing astrocyte function might lead to the discovery of new treatments for the diseased brain.
Jimmy Garnier (LAMA, Univ. Savoie Mont-Blanc): Mutualism at the leading edge: Insights into the eco-evolutionary dynamics of host-symbiont communities during range expansion
Résumé : The evolution of mutualism between host and symbiont communities plays an essential role in maintaining ecosystem function and should therefore have a profound effect on their range expansion dynamics. In particular, the presence of mutualistic symbionts at the leading edge of a host-symbiont community should enhance its propagation in space. I will present a theoretical framework that captures the eco-evolutionary dynamics of host-symbiont communities, and allow us to investigate how the evolution of resource exchange may shape community structure during range expansion.
21 juin 2024: Journée 3 à Grenoble
Julien Chevallier (LJK, Univ Grenoble Alpes) : TBA
