Design is ubiquitous, and computer graphics has been an integral tool for design since the early days of CAD. The relevance of CAD in computer graphics is experiencing a revival, and this is also affecting the impact of game technologies on design applications. Game physics provide a means to create computer models of objects, bodies, or other dynamic phenomena, which can then be used within a CAD application. Game technologies enjoy the opportunity to transform the way in which we approach design. This talk will cover several examples of computer graphics research, where physics-based simulation models, together with optimization tools, build the engine of design applications. The examples cover the animation of diverse materials such as skin, soft tissue, cloth, or flexible fabrication materials, and they find impact in diverse applications such as medicine, fabrication, or fashion.