Aug 19 2015

Focus on a joint research project: CARDIO

CARDIO (2008-2013)

Physiological flow modeling in complex and moving geometries

Principal Investigators :

  • Dr. Irene Vignon-Clementel, REO project-team, Inria Paris-Rocquencourt
  • Dr. Charles Taylor, Stanford University & Heartflow

Research objectives:

CARDIO workshop poster

CARDIO workshop poster

The REO project-team of Inria and the Cardiovascular Biomechanics Research laboratory (CVBRL) have both developed numerical methods geared towards cardiovascular applications. They further share similar goals and both interact with the medical and industrial communities, yet approaches and developed methodologies are complementary.

Scientific achievements:

CARDIO worked on the challenges of bringing together medical data and numerical simulations of blood and air flow:

  • Clinically based geometry & boundary conditions: for the fluid – air and flow – the rest of the system not modeled in the detailed 3D part is taken into account, and for the vessel wall taking into the surrounding tissue viscoelastic effects.
  • 3 applications were specifically studied: single ventricle repair (congenital heart disease), aorta in healthy and disease states, emphysema (respiratory disease).

Publications and Awards:

  • 6 PhD theses.
  • 15 Journal articles.
  • Software advances.
  • Leducq funded transatlantic network of excellence.
  • 2 student prizes and 2 student fellowships.
  • ERC Starting Grant of C. A. Figueroa (KCL).

Selected publication:

G. Troianowski, C. Taylor, A., J. Feinstein, A., I. VignonClementel, E., Three dimensional simulations in Glenn patients: clinically based boundary conditions, hemodynamic results and sensitivity to input data, Journal of Biomechanical Engineering 133, 11, 2011.

Follow up:

While CARDIO permitted to deliver state of the art responses. to scientific challenges, follow-up research is undertaken within existing grants or new avenues: more automatized parameter estimation from clinical data (REO-INRIA, UCSD and Leducq network; M3DISIM-INRIA and KCL with Figueroa ERC grant); Verification/validation (Figueroa ERC grant, REO Air Liquide collaboration) ; Uncertainty analysis (Leducq network, …) ; Disease assesment.

More about CARDIO: https://idal.inria.fr/cardio/